Dr. Jana Selent

Assistant Professor at the UPF  

Miguel Servet Researcher at the Hospital del Mar

Pharmacoinformatics group (PhI)

Research Group on Biomedical Informatics (GRIB)


Cuadro de texto: News										2012

- January  2nd, 2012 -


Radio Broadcast on SWR2 (radio frequency 107.85 in Berlin area): In-silico drug discovery, Interview with Dr. Jana Selent by Luise Wagner.


In silico” is an analogue to the Latin phrases “in vivo” and “in vitro” and means "performed on computer or via computer simulation." If you want to know more about how a drug is born and developed in a virtual nanocosmos, listen to this broadcast (in German).  



- April 2012 -


New publications:

Kaczor AA, Guixà-González R, Carrió P, Obiol-Pardo C, Pastor M, Selent J. Fractal dimension as a measure of surface roughness of G protein-coupled receptors: implications for structure and function. Mol. Model. 2012, in press. (click)

Fernández-Mariño AI, Porras C, González-Rodríguez P, Selent J, Pastor M, Ureña J, CastellanoA, Valverde MA, and Fernández-Fernández JM. Tungstate activates BK channels in a β subunit- and Mg2+-dependent manner: relevance for arterial vasodilation. in Cardiovasc Res. 2012, in press. (click)



- March  2012 -


Upcoming talk:

Internal meeting: “Learning from Individuals & Special Cases: From Chemical Probes and Receptors to Personalized Medicine Wednesday, March 21, 2012, Marburg, Germany

Lecture: Advances in Predicting G Protein-Coupled Receptor Complexes (Jana Selent)


 - February  2012 -


La Marató Project - GPCR Dimers as Drug Targets: New publication!

R. Guixà-González, A. Bruno, M. Martí-Solano and J. Selent: Crosstalk within GPCR Heteromers in Schizophrenia and Parkinson's Disease: Physical or Just Functional? in Curr Med Chem, 2012.

Congratulations to Juanma!

Dr. Juan Manuel Ramírez Anguita obtained the fellowship of “ALIANZA 4 UNIVERSITATS” and is going to join our lab in October 2012! 



- July 2012 -




- September 2012 -




- November 2012 -





New publication:

Bruno A, Costantino G, de Fabritiis G, Pastor M, Selent J. Membrane-Sensitive Conformational States of Helix 8 in the Metabotropic Glu2 Receptor, a Class C GPCR. PLOS ONE 2012, in press



Membrane-lipid mediated effects on GPCRs

If you are interested in the current state of simulating membrane-lipid mediated effects on GPCRs, check out our latest Hot Topic Article in Curr Med Chem 2012 (click).



Cuadro de texto: News										2013

- January 2013 -




Course of Structural Biology at the Pompeu Fabra University starts on the 7th of January 2013! (click)


- February 2013 -




- May 2013 -




The project “Molecular dynamics of GPCRs in lipid rafts of CNS disease” has been awarded with computational resources from the Barcelona Supercomputing Center.

Our new hot topic article outlines the current perception of the complex nature of GPCR functionality: Novel Insights into Biased Agonism at G Protein-Coupled Receptors and their Potential for Drug Design Martí-Solano M, Guixà-González R, Sanz F, Pastor M, Selent J. Curr Pharm Des. 2013 Apr 25. (click)




- October 2013 -




Upcoming talk: Simulating Membrane Lipid-Mediated Effects on GPCRs at the CECAM workshop: Coupling between protein, water, and lipid dynamics in complex biological systems: Theory and Experiments, September 24, 2013 to September 27, 2013, Lausanne, Switzerland (click)

- June 2013 -




Upcoming talk: Allosteric Modulation of GPCRs: Towards New Drug Discovery Strategies for the Treatment of CNS Disorders. Drug Discovery & Therapy, World Congress 2013, June 3rd – 6th, 2013, John B. Hynes Memorial Convention Center, Boston, USA (click)

- September 2013 -




NEWS: Pre-release of the MEMBPLUGIN TOOL for VMD. Check it out! (click)

Upcoming Workshop and talk: Simulating the Complex Nature of Membrane Lipid-GPCR Interaction Using the MEMBPLUGIN TOOL at the GLISTEN meeting, October 9, 2013,  Warsaw, Poland (click)


Cuadro de texto: News										2014

- Januar 2014 -




GLISTEN SPRING MEETING 2014 will take place on the 28th/29th April in Barcelona at the Biomedical Research Park Registration will open soon!

Course of Structural Biology at the Pompeu Fabra University starts on the 9th of January 2014! (click)

Cuadro de texto: News										2015

- September 2015 -


2nd edition of the course “Introduction to Drug Design” at the Pompeu Fabra University. Starting date: September 23rd, 11:30, AULA 61.327, Content of the course (click)


- May 2015 -


New biased agonists for the serotonin 5-HT2A receptor!

Combining accelerated molecular dynamics simulation and rational drug design strategies, we discovered novel compounds with an unprecedented level of signaling bias at the 5-HT2A receptor. These compounds can help interrogate the importance of particular pathways in conditions like schizophrenia (pubmed).


- April 2015 -


GLISTEN SPRING MEETING 2015 will take place in April 1-2, 2015, Allschwill/Actelion, Switzerland (click)










Allschwill/Actelion, Switzerland (click)

- April 2016 -


Upcoming talk at the GPCR conference—GLISTEN Meeting 2016 in Erlangen

“The meeting will focus on the interplay between medicinal chemistry, chemical biology, structural biology and molecular pharmacology, leading to an improved understanding on the structure and function of GPCRs...”  (click)


Within this meeting, we present our newest data on: “A gate for membrane cholesterol into the interior of GPCRs”  on Thursday, April 7th.
















Cuadro de texto: News										2016

- February 2016 -


The membrane environment can make the difference for GPCR functionality.


Several studies have found substantially lower

levels of docosahexaenoic acid (DHA) in the

brains of individuals with mental or neurological

disorders. Can this DHA decrease impact

membrane proteins such as GPCRs? (pubmed)



- January 2016 -


“In silico data tsunami: will you survive?” 


Wednesday 27th January: 12:00 -15:00, Sala Charles

Darwin, PRBB, Barcelona (agenda). This session is part

of the “Record keeping and data management

campaign for PRBB scientists” initiated by

the Good Scientific Practice Group.


Course of Structural Biology at the Pompeu Fabra University starts on the 9th of January 2016! (click)

- October 2016 -


3rd edition of the course “Introduction to Drug Design” at the Pompeu Fabra University. Starting date: October  3rd, 11:00, AULA 61.103, Content of the course (click)


- September 2016 -


GPCRmd project. We present the progress of the GPCRmd project at next GPCR meeting, September 25th, Prague, Czech Republic (click)

Cuadro de texto: News										2017

- March 2017 -


The novel GPCRmd database (www.gpcrmd.org) will be presented at the GLISTEN Symposium in Porto , Portugal, on 29-31 March 2017 (click).


- January 2017 -

Course of Structural Biology at the Pompeu Fabra University starts on the 9th of January 2017! (click)